![]() A double-blind, crossover trial has confirmed that chromium supplementation improves glucose and lipid levels while decreasing medication dosage in type 2-diabetes. Daily intake of 8mcg/kg body weight of chromium is more effective than 4mcg/kg in women with gestational diabetes ( source) and steroid-induced diabetes can be reversed with doses of 600mcg/day ( source). ![]() The overall requirement of chromium is relative to the degree of glucose intolerance, and while a higher intake is more effective, 200mcg of supplemental chromium is adequate to improve mild glucose intolerance in individuals. It should be noted that the beneficial effects of chromium appear to only be relevant at levels which are five-fold higher than the upper limit which is supposed to be the estimated safe and adequate daily intake without any documented side-effects. Chromium picolinate at 1,000mcg/day has had notable beneficial effects on hemoglobin A1C, glucose, insulin and cholesterol levels in those with type-2 diabetes in a clinical trial ( source). Those with glucose intolerance such as type-1, type-2, gestational, and steroid-induced diabetes have all shown improved glucose metabolism with supplemental chromium ( source). Clinical Uses:ĭietary sugar loads increase the natural rate of urinary chromium loss by 300% for 12 hours ( source). However, the therapeutic dose ranges from 200-2000mcg/day. Dose:Ī safe and adequate daily intake of chromium is between 50-200mcg. Some recommend barley as a good source for chromium. It can be found in brewers yeast, cheese, molasses, wheat germ and whole grains, sugar beets, eggs, meat and seafood. Food sources:Ĭhromium is found in various foods in quantities that correlate to the presence in the soil. Chromodulin is believed to play a role in the auto-amplification of insulin signalling ( source). Glucose tolerance factor also consists of two nicotinic acid molecules and a small oligopeptide, chromodulin. Glucose tolerance factor is believed to aid glucose transport across the cell surface as well as mediate the effects of insulin. Trivalent chromium is an essential component of glucose tolerance factor. It activates insulin receptor kinase which increases insulin sensitivity ( source). Insulin binding to cells seems to be increased by the presence of chromium as well as the number of insulin receptors. Mechanism of action:Ĭhromium plays an important role in carbohydrate, fat and protein metabolism and has an impact on the expression of genes and nucleic acid synthesis. Chromium activates phosphoglucosonetase and other enzymes. Chromium enhances the effects of insulin. In its trivalent state, it is critical for carbohydrate, lipid and nucleic acid metabolism.
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